Identification of Gelatinases in Prostate Cancer Cells

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Prostate cancer remains one of the most common oncological diseases among men. Gelatinases, such as MMP-13 and MMP-7, play a key role in tumor invasion and metastasis. Prostate-specific antigen (PSA) and metalloproteinases are considered as potential biomarkers and targets for prostate cancer diagnosis and therapy. The study used gelatin zymography to assess gelatinase activity in the PC-3 prostate cancer cell line. The results showed the presence of protein bands corresponding to gelatinase activity in the size range of 20, 28 and 37 kDa, which coincides with the activity of MMP-13, MMP-7 and PSA in PC-3 cells. The results showed the presence of protein bands corresponding to the proteolytic activity of gelatinases in the size range of 20, 28 and 37 kDa, which coincides with the activity of MMP-13, MMP-7 and PSA. Thus, gelatinases MMP-13, MMP-7 and PSA were identified in prostate cancer cells, which can be used as markers of aggressiveness and progression of prostate cancer.

作者简介

N. Akentieva

Federal Research Center for Problems of Chemical Physics and Medical Chemistry, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: na_aken@icp.ac.ru
俄罗斯联邦, Chernogolovka, Moscow Region

A. Gizatullin

Federal Research Center for Problems of Chemical Physics and Medical Chemistry, Russian Academy of Sciences

Email: na_aken@icp.ac.ru
俄罗斯联邦, Chernogolovka, Moscow Region

S. Shushanov

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: na_aken@icp.ac.ru
俄罗斯联邦, Moscow

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