MONOCATIONIC CHLORIN PHOTOSENSITIZER FOR EFFICIENT PHOTOINACTIVATION OF ANTIBIOTIC RESISTANT GRAM-NEGATIVE MICROORGANISMS

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

We propose a monocationic chlorin photosensitizer for antimicrobial photodynamic therapy of superficial localized infections. The antimicrobial activity of this specie towards planktonic forms of nosocomial anti-biotic resistant pathogens, viz. Pseudomonas aeruginosa, Enterobacter cloacae и Acinetobacter baumannii was studied and compared with the activity of the well-established photosensitizer “Fotoran e6”. Our results do indicate that monocationic chlorin provides efficient photoinactivation of all the three microorganisms and can be considered as a new agent for antimicrobial photodynamic therapy.

About the authors

A. V. Kustov

G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences (ISC RAS)

Author for correspondence.
Email: kustov26@yandex.ru
Russian, 153045, Ivanovo

N. V. Kukushkina

G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences (ISC RAS)

Email: kustov26@yandex.ru
Russian, 153045, Ivanovo

E. V. Lyalyakina

Ivanovo Regional Clinical Hospital

Email: kustov26@yandex.ru
Russian, 153000, Ivanovo

N. N. Solomonova

Ivanovo Regional Clinical Hospital

Email: kustov26@yandex.ru
Russian, 153000, Ivanovo

A. K. Gagua

National Medical Research Center for Otorhinolaryngology of the Federal Medico-Biological Agency of Russia

Email: kustov26@yandex.ru
Russian, 123182, Moscow

O. I. Koifman

G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences (ISC RAS); Ivanovo State University of Chemistry and Technology

Email: kustov26@yandex.ru
Russian, 153045, Ivanovo; Russian, 153000, Ivanovo

D. B. Berezin

Ivanovo State University of Chemistry and Technology

Email: kustov26@yandex.ru
Russian, 153000, Ivanovo

References

  1. Wainwright M., Maisch T., Nonell S., Plaetzer K., Almeida A., Tegos G.P., Hamblin M.R. // Lancet Infect. Dis. 2017. V. 17. № 2. P. e49–e55. https://doi.org/10.1016/S1473-3099(16)30268-7
  2. Banin E., Hughes D., Kuipers O.P. // FEMS Microbiol. Rev. 2017. V. 41. № 3. P. 450–452. https://doi.org/10.1093/femsre/fux016
  3. Cieplik F., Deng D., Crielaard W., Buchalla W., Hellwig E., Al-Ahmad A., Maisch T. // Critical Rev. Microbiol. 2018. V. 44. № 5. P. 571–589. https://doi.org/10.1080/1040841X.2018.1467876
  4. Кустов А.В., Березин Д.Б., Стрельников А.И., Лапочкина Н.П. Противоопухолевая и антимикробная фотодинамическая терапия: механизмы, мишени, клинико-лабораторные исследования: руководство. А.К. Гагуа (ред.). М.: Ларго, 2020. 108 с.
  5. Hamblin M. // Curr. Opin. Microbiol. 2016. V. 33. P. 67–73. https://doi.org/10.1016/j.mib.2016.06.008
  6. Kustov A.V., Kustova T.V., Belykh D.V., Khudyaeva I.S., Berezin D.B. // Dyes Pigm. 2020. V. 173. P. 107948. https://doi.org/10.1016/j.dyepig.2019.107948
  7. Fonseca A.S., Mencalha A.L., Paoli F. // Photodiagnosis Photodyn Ther. 2021. V. 35. P. 102430. https://doi.org/10.1016/j.pdpdt.2021.102430
  8. Гейниц А.В., Толстых П.И., Дербенев В.А., Тамразова О.Б., Гусейнов А.И., Морозова Т.В., Гульмурадо- ва Н.Т. Фотодинамическая терапия гнойных и длительно не заживающих ран. Пособие для врачей. М.: МЗ РФ, 2004. 15 с.
  9. Van Straten D., Mashayekhi V., Bruijn H.S., Oliveira S., Robinson D.J. // Cancers. 2017. V. 9. № 2. P. 1–54. https://doi.org/10.3390/cancers9020019
  10. Otvagin V.F., Kuzmina N.S., Krylova L.V., Volove-tsky A.B., Nyuchev A.V., Gavryushin A.E., Meshkov I.N., Gorbunova Y.G., Romanenko Y.V., Koifman O.I., Balalaeva I.V., Fedorov A.Y. // J. Med. Chem. 2019. V. 62. P. 11182. https://doi.org/10.1021/acs.jmedchem.9b01294
  11. Kustov A.V., Smirnova N.L., Privalov O.A., Moryganova T.M., Strelnikov A.I., Morshnev Ph.K., Koifman O.I., Lubimtsev A.V., Kustova T.V., Berezin D.B. // J. Clin. Med. 2022. V. 11. № 1. P. 233. https://doi.org/10.3390/jcm11010233
  12. Yao L., Rong Q., Zaat S.A.J., Breukink E., Heger M. // J. Clin. Transl. Res. 2015. V. 1. № 3. P. 140–167. https://doi.org/10.18053/jctres.201503.002
  13. Drulis-Kawa Z., Bednarkiewicz A., Bugla G., Stręk W., Doroszkiewicz W. // Adv. Clin. Exp. Med. 2006. V. 15. № 2. P. 279–283. http://www.advances.umed.wroc.pl/en/article/ 2006/15/2/279
  14. Hamblin M.R. // Expert Review of Anti-infective Therapy. 2017. V. 15. № 11. P. 1059–1069. https://doi.org/10.1080/14787210.2017.1397512
  15. Vieira C., Gomes A.T.P.C., Mesquita M.Q., Moura N.M.M., Neves M.G.P.M.S., Faustino M.A.F., Almeida A. // Front. Microbiol. 2018. V. 9. P. 2665. https://doi.org/10.3389/fmicb.2018.02665
  16. Березин Д.Б., Солодухин Т.Н., Шухто О.В., Белых Д.В., Старцева О.М., Худяева И.С., Кустов А.В. // Изв. АН. Сер. хим. 2018. Т. 67. № 7. С. 1273–1279.
  17. Batov D.V., Kustov A.V., Kruchin S.O., Makarov V.V., Berezin D.B. // J. Struct. Chem. 2019. V. 60. № 3. P. 443–448. https://doi.org/10.26902/JSC_id39509
  18. Kustov A.V., Morshnev Ph.K., Kukushkina N.V., Krestyaninov M.A., Smirnova N.L., Berezin D.B., Kokurina G.N., Belykh D.V. // C. R. Chimie. 2022. V. 97. № 1. P. 97–102. https://doi.org/10.5802/crchim.158
  19. Huang L., Dai T., Hamblin M.R. Antimicrobial photodynamic inactivation and photodynamic therapy for infections. In: Photodynamic Therapy. Methods and Protocols. Gomer C.J. (Ed.). New York: Springer Dordrecht Heidelberg London. 2010. P. 155–174.
  20. Gsponer N.S., Spesia M.B., Durantini N.E. // Photodiagn. Photodyn. Ther. 2015. V. 12. № 1. P. 67–75. https://doi.org/10.1016/j.pdpdt.2014.12.004

Supplementary files

Supplementary Files
Action
1. JATS XML
2.

Download (53KB)
3.

Download (92KB)
4.

Download (92KB)
5.

Download (68KB)

Copyright (c) 2023 А.В. Кустов, Н.В. Кукушкина, Е.В. Лялякина, Н.Н. Соломонова, А.К. Гагуа, О.И. Койфман, Д.Б. Березин