Preparation, Characterization, and Anticancer Activity Assessment of Chitosan/TPP Nanoparticles Loaded with Echis carinatus Venom

  • 作者: Mehrabi M.1, Bitaraf F.2, Vahedi H.3, Alizadeh M.4, Bernkop-Schnürch A.5, Kancha M.6
  • 隶属关系:
    1. Department of Medical Nanotechnology, School of Medicine,, Shahroud University of Medical Sciences
    2. Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Science
    3. Department of Gastroenterology, School of Medicine,, Shahroud University of Medical Sciences
    4. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences
    5. Department of Pharmaceutical Technology,, University of Innsbruck, Institute of Pharmacy, Center for Chemistry and Biomedicine
    6. Student Research Committee, School of Medicine,, Shahroud University of Medical Sciences
  • 期: 卷 24, 编号 7 (2024)
  • 页面: 533-543
  • 栏目: Oncology
  • URL: https://snv63.ru/1871-5206/article/view/644267
  • DOI: https://doi.org/10.2174/0118715206279731231129105221
  • ID: 644267

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Aims and Background:Echis carinatus venom is a toxic substance naturally produced by special glands in this snake species. Alongside various toxic properties, this venom has been used for its therapeutic effects, which are applicable in treating various cancers (liver, breast, etc.).

Objective:Nanotechnology-based drug delivery systems are suitable for protecting Echis carinatus venom against destruction and unwanted absorption. They can manage its controlled transfer and absorption, significantly reducing side effects

Methods:In the present study, chitosan nanoparticles were prepared using the ionotropic gelation method with emulsion cross-linking. The venom's encapsulation efficiency, loading capacity, and release rate were calculated at certain time points. Moreover, the nanoparticles' optimal formulation and cytotoxic effects were determined using the MTT assay.

Results:The optimized nanoparticle formulation increases cell death induction in various cancerous cell lines. Moreover, chitosan nanoparticles loaded with Echis carinatus venom had a significant rate of cytotoxicity against cancer cells.

Conclusion:It is proposed that this formulation may act as a suitable candidate for more extensive assessments of cancer treatment using nanotechnology-based drug delivery systems.

作者简介

Mohsen Mehrabi

Department of Medical Nanotechnology, School of Medicine,, Shahroud University of Medical Sciences

编辑信件的主要联系方式.
Email: info@benthamscience.net

Fatemeh Bitaraf

Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Science

Email: info@benthamscience.net

Hamid Vahedi

Department of Gastroenterology, School of Medicine,, Shahroud University of Medical Sciences

Email: info@benthamscience.net

Morteza Alizadeh

Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences

Email: info@benthamscience.net

Andreas Bernkop-Schnürch

Department of Pharmaceutical Technology,, University of Innsbruck, Institute of Pharmacy, Center for Chemistry and Biomedicine

Email: info@benthamscience.net

Maral Kancha

Student Research Committee, School of Medicine,, Shahroud University of Medical Sciences

Email: info@benthamscience.net

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