Biosynthesis and Anticancer Activity of Genistein Glycoside Derivatives


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Abstract

As a beneficial natural flavonoid, genistein has demonstrated a wide range of biological functions via regulating a number of targets and signaling pathways, such as anti-cancer, antioxidant, antibacterial, antiinflammatory, antifungal, antiviral, iron chelation, anti-obesity, anti-diabetes, and anti-hypertension. PubMed/Medline and Web of Science were searched using appropriate keywords until the end of December 2023. Despite its many potential benefits, genistein’s clinical application is limited by low hydrophilicity, poor solubility, and suboptimal bioavailability due to its structure. These challenges can be addressed through the conversion of genistein into glycosides. Glycosylation of active small molecules may enhance their solubility, stability, and biological activity. In recent years, extensive research has been conducted on the synthesis, properties, and anticancer activity of glycoconjugates. Previous reviews were devoted to discussing the biological activities of genistin, with a little summary of the biosynthesis and the structure-activity relationship for their anticancer activity of genistein glycoside derivatives. Therefore, we summarized recent advances in the biosynthesis of genistein glycosylation and discussed the antitumor activities of genistein glycoside derivatives in a structure-activity relationship, which may provide important information for further development of genistein derivatives.

About the authors

Xing Zheng

Department of Pharmacy, Hunan Vocational College of Science and Technology

Email: info@benthamscience.net

Jun Zhang

Department of Pharmacy, Hunan Vocational College of Science and Technology

Email: info@benthamscience.net

Shun Liu

Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China

Email: info@benthamscience.net

Yingzi Yu

Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China

Email: info@benthamscience.net

Qingying Peng

Institute of Pharmacy and Pharmacology, Hengyang Medicinal School,, University of South China

Email: info@benthamscience.net

Yaling Peng

Institute of Pharmacy and Pharmacology, Hengyang Medicinal School,, University of South China

Email: info@benthamscience.net

Xu Yao

Institute of Pharmacy and Pharmacology, Hengyang Medicinal School,, University of South China

Author for correspondence.
Email: info@benthamscience.net

Xingxing Peng

Institute of Pharmacy and Pharmacology, Hengyang Medicinal School,, University of South China

Author for correspondence.
Email: info@benthamscience.net

Jing Zhou

Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China

Author for correspondence.
Email: info@benthamscience.net

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