Anticancer Activity of Sargassum fluitans Extracts in Different Cancer Cells

  • Авторлар: González-Garrido J.1, Gómez-García J.2, Hernández-Abreu O.1, Olivares-Corichi I.3, Pereyra-Vergara F.3, García-Sánchez J.4
  • Мекемелер:
    1. Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), División Académica de Ciencias Básicas. Laboratorio de Bioquímica y Biología molecular, Universidad Juarez Autonoma de Tabasco
    2. Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), División Académica de Ciencias Básicas. Laboratorio de Bioquímica y Biología molecular,, Universidad Juarez Autonoma de Tabasco
    3. Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional. Laboratorio de Oncología Molecular y Estrés Oxidativo,, Instituto Politecnico Nacional
    4. Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional. Laboratorio de Oncología Molecular y Estrés Oxidativo, Instituto Politecnico Nacional
  • Шығарылым: Том 24, № 10 (2024)
  • Беттер: 745-754
  • Бөлім: Oncology
  • URL: https://snv63.ru/1871-5206/article/view/643695
  • DOI: https://doi.org/10.2174/0118715206282983240215050314
  • ID: 643695

Дәйексөз келтіру

Толық мәтін

Аннотация

Background:The arrival of large quantities of Sargassum in the Mexican Caribbean Sea has generated major environmental, health and economic problems. Although Sargassum has been used in the generation of some commercial products, few studies have described its possible applications as a source of compounds with anticancer activity.

Objective:This study aimed to evaluate the antiproliferative effects of different Sargassum extracts on various cancer cell lines. Furthermore, LC/QTOF-MS was used to identify the compounds related to the antiproliferative effect.

Methods:First, determination of the seaweed was performed, and dichloromethane, chloroform and methanol extracts were obtained. The extracts were evaluated for their antiproliferative effects by MTT in breast (MDAMB- 231 and MCF-7), prostate (DU-145), lung (A549) and cervical (SiHa) cancer cell lines. Finally, LC/QTOFMS identified the compounds related to the antiproliferative effect.

Results:The authentication showed Sargassum fluitans as the predominant species. The extracts of dichloromethane and chloroform showed an antiproliferative effect. Interestingly, the fractionation of the chloroform extract showed two fractions (FC1 and FC2) with antiproliferative activity in MDA-MB-231, SiHa and A549 cancer cell lines. On the other hand, three fractions of dichloromethane extract (FD1, FD4 and FD5) also showed antiproliferative effects in the MDA-MB-231, MCF-7, SiHa and DU-145 cancer cell lines. Furthermore, LC/QTOF-MS revealed the presence of eight major compounds in FC2. Three compounds with evidence of anticancer activity were identified (D-linalool-3-glucoside, (3R,4S,6E,10Z)-3,4,7,11-tetramethyl-6,10-tridecadienal and alpha-tocotrienol).

Conclusion:These findings showed that Sargassum fluitans extracts are a possible source of therapeutic agents against cancer and could act as scaffolds for new drug discovery.

Авторлар туралы

José González-Garrido

Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), División Académica de Ciencias Básicas. Laboratorio de Bioquímica y Biología molecular, Universidad Juarez Autonoma de Tabasco

Email: info@benthamscience.net

Javier Gómez-García

Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), División Académica de Ciencias Básicas. Laboratorio de Bioquímica y Biología molecular,, Universidad Juarez Autonoma de Tabasco

Email: info@benthamscience.net

Oswaldo Hernández-Abreu

Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), División Académica de Ciencias Básicas. Laboratorio de Bioquímica y Biología molecular, Universidad Juarez Autonoma de Tabasco

Email: info@benthamscience.net

Ivonne Olivares-Corichi

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional. Laboratorio de Oncología Molecular y Estrés Oxidativo,, Instituto Politecnico Nacional

Email: info@benthamscience.net

Fernando Pereyra-Vergara

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional. Laboratorio de Oncología Molecular y Estrés Oxidativo,, Instituto Politecnico Nacional

Email: info@benthamscience.net

José García-Sánchez

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional. Laboratorio de Oncología Molecular y Estrés Oxidativo, Instituto Politecnico Nacional

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

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