Stem Cell Therapy for the Treatment of Parkinson's Disease: What Promise Does it Hold?


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Abstract

Parkinson's disease (PD) is a common, progressive neurodegenerative disorder characterized by substantia nigra dopamine cell death and a varied clinical picture that affects older people. Although more than two centuries have passed since the earliest attempts to find a cure for PD, it remains an unresolved problem. With this in mind, cell replacement therapy is a new strategy for treating PD. This novel approach aims to replace degenerated dopaminergic (DAergic) neurons with new ones or provide a new source of cells that can differentiate into DAergic neurons. Induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), and embryonic stem cells (ESCs) are among the cells considered for transplantation therapies. Recently disease-modifying strategies like cell replacement therapies combined with other therapeutic approaches, such as utilizing natural compounds or biomaterials, are proposed to modify the underlying neurodegeneration. In the present review, we discuss the current advances in cell replacement therapy for PD and summarize the existing experimental and clinical evidence supporting this approach.

About the authors

Ava Nasrolahi

Infectious Ophthalmologic Research Cente, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences

Email: info@benthamscience.net

Zahra Shabani

Center for Cerebrovascular Research, University of California

Email: info@benthamscience.net

Saeed Sadigh-Eteghad

Neurosciences Research Center, Tabriz University of Medical Sciences

Email: info@benthamscience.net

Hanieh Salehi-Pourmehr

Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences

Email: info@benthamscience.net

Javad Mahmoudi

Neurosciences Research Center, Tabriz University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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