Selective voltammetric determination of dopamine on an electrode modified with palladium particles and a molecular imprinted polymer from nicotinamide

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Аннотация

A method for manufacturing a glass-carbon electrode with electrodeposited palladium particles and a molecular imprinted polymer from nicotinamide for the determination of dopamine in the presence of structurally related compounds has been developed. The use of a polymer with specific recognition centers complementary to the template molecule led to an increase in the sensitivity and selectivity of dopamine detection. Immobilization of palladium particles on the electrode surface made it possible to increase the selectivity of the voltammetric determination of dopamine in the presence of adrenaline and norepinephrine. The potential difference of the oxidation peaks of these compounds is 200 mV. The linear bilogarithmic dependence of the analytical signal on the dopamine concentration is observed in the range from 5.0 × 10–9 to 5.0 × 10–3 М. The proposed method was tested in the analysis of urine samples.

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Авторлар туралы

L. Shaidarova

KFU

Хат алмасуға жауапты Автор.
Email: larisashaidarova@mail.ru

Butlerov Institute of Chemistry

Ресей, 18 Kremlyovskaya St., Kazan, 420008

I. Chelnokova

KFU

Email: larisashaidarova@mail.ru

Butlerov Institute of Chemistry

Ресей, 18 Kremlyovskaya St., Kazan, 420008

D. Khairullina

KFU

Email: larisashaidarova@mail.ru

Butlerov Institute of Chemistry

Ресей, 18 Kremlyovskaya St., Kazan, 420008

Y. Leksina

KFU

Email: larisashaidarova@mail.ru

Butlerov Institute of Chemistry

Ресей, 18 Kremlyovskaya St., Kazan, 420008

H. Budnikov

KFU

Email: larisashaidarova@mail.ru

Butlerov Institute of Chemistry

Ресей, 18 Kremlyovskaya St., Kazan, 420008

Әдебиет тізімі

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Әрекет
1. JATS XML
2. Scheme 1. Electropolymerization of nicotinamide.

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3. Scheme 2. Electrooxidation of dopamine.

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4. Fig. 1. Cyclic voltammograms obtained on unmodified GCE (1) and MIP-GCE (2) in the presence of dopamine (c = 5×10–3 M) against the background of 0.1 M H2SO4 (a); dependence of I / о during dopamine electrooxidation on the MIP-GCE electrode (b).

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5. Fig. 2. Cyclic voltammograms obtained on MIP-Pd-GCE (1, 3) and Pd-MIP-GCE (2) in the absence (1) and presence (2, 3) of dopamine (c = 5 × 10–3 M) against the background of 0.1 M H2SO4 (a); dependence of I / о during dopamine electrooxidation on MIP-Pd-GCE (b).

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6. Fig. 3. Nyquist diagrams obtained on unmodified GCE (1), on Pd-GCE (2) (a), on Pd-MIP-GCE (3) and MIP-Pd-GCE (4) (b) in the presence of 1.0 mM K4[Fe(CN)6]/K3Fe(CN)6 against the background of 0.1 M KCl in the frequency range from 0.01 Hz to 10 kHz with an amplitude of 5 mV at a potential of 0.24 V.

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7. Fig. 4. Cyclic voltammograms obtained on MIP-Pd-GCE during electrooxidation of dopamine (c = 5×10–3 M) in the presence of adrenaline with a concentration of 5 × 10–5 (1), 5 × 10–4 (2), 5 × 10–3 (3) M (a) and noradrenaline with a concentration of 5 × 10–5 (1), 5 × 10–4 (2), 5 × 10–3 (3) M (b) against the background of 0.1 M H2SO4.

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