Possibilities of a supramolecular system based on hexamolybdenum cluster complexes in the determination of amitriptyline by amperometric immunosensors in human urine

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A method for the determination of amitriptyline as a representative of tricyclic antidepressants by immunosensors using supramolecular systems based on hexamolybdenum cluster complexes in human urine was developed. These complexes are electrochemically active and give a stable analytical signal, which was utilized in the development of amperometric immunosensors. Luminescence and dynamic light scattering methods were applied to prove the formation of a supramolecular system of self-organized hexamolybdenum nanoparticles and chitosan molecules. A composite material based on hexamolybdenum cluster complexes combined with reduced graphene oxide was developed. The working range of amitriptyline concentrations when determined by amperometric immunosensor was 1 × 10-9 -1 × 10-4 M, the lower limit of detectable contents lies at the level of 5 × 10-10 M, the content of amitriptyline in urine samples – at the level of (n – 7) × 10-8 M. Comparison of the results of the analysis by amperometric immunosensor and polarization fluorescence immunoassay showed the absence of significant systematic errors. The ability to determine amitriptyline in biological fluids makes it possible to select the optimal therapeutic dose of the drug, i.e., to develop approaches to the creation of personalized medicine.

Sobre autores

D. Brusnitsyn

Kazan (Volga Region) Federal University

Autor responsável pela correspondência
Email: brussman@mail.ru

A.M. Butlerov Chemical Institute

Rússia, 420008 Kazan

E. Medyantseva

Kazan (Volga Region) Federal University

Email: brussman@mail.ru

A.M. Butlerov Chemical Institute

Rússia, 420008 Kazan

A. Ramazanova

Kazan (Volga Region) Federal University

Email: brussman@mail.ru

A.M. Butlerov Chemical Institute

Rússia, 420008 Kazan

A. Prytkova

Kazan (Volga Region) Federal University

Email: brussman@mail.ru

A.M. Butlerov Chemical Institute

Rússia, 420008 Kazan

E. Karimova

Interregional Clinical and Diagnostic Center

Email: brussman@mail.ru
Rússia, 420101 Kazan

Y. Elistratova

Federal Research Center “Kazan Scientific Center” of the Russian Academy of Sciences

Email: brussman@mail.ru

A.E. Arbuzov Institute of Organic and Physical Chemistry

Rússia, 420088 Kazan

A. Mustafina

Federal Research Center “Kazan Scientific Center” of the Russian Academy of Sciences

Email: brussman@mail.ru

A.E. Arbuzov Institute of Organic and Physical Chemistry

Rússia, 420088 Kazan

M. Sokolov

A.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: brussman@mail.ru
Rússia, 630090 Novosibirsk

S. Eremin

M.V. Lomonosov Moscow State University

Email: brussman@mail.ru

Department of Chemistry

Rússia, 119991 Moscow

L. Mukhametova

M.V. Lomonosov Moscow State University

Email: brussman@mail.ru

Department of Chemistry

Rússia, 119991 Moscow

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