A theory of the evolutionary role of hereditary tumors (carcino-evo-devo): the history and the current state. Part 4. A general theory of increasing biological complexity in progressive evolution

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New chapters of carcino-evo-devo theory are devoted to tumor participation in biological computational processes; the principle of increase in biological complexity; and the formula of complexity growth in progressive evolution based on carcino-evo-devo diagrams. The conclusion is made that new chapters establish the basis of a more general theory — the theory of the increase in complexity, the special part of which is the carcino-evo-devo theory.

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A. Kozlov

Vavilov Institute of General Genetics, Russian Academy of Sciences; Biomedical Center; Peter the Great St. Petersburg Polytechnic University

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Email: contact@biomed.spb.ru
俄罗斯联邦, Moscow; St. Petersburg; St. Petersburg

参考

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2. Fig. 1. Carcino-evo-devo diagrams showing the coevolution of individual and neoplastic development (a) and four successive steps of progressive evolution with the intermediate form Carcino (b). (a) Main diagram. Devo — normal ontogeneses; Carcino — ontogeneses with heritable tumors; Evo — progressive evolution of ontogeneses. (b) Main diagram, expanded in evolutionary time. Devo 1 — ancestral organism; Devo 2, Devo 3, Devo 4, and Devo 5 — ontogeneses with evolutionarily new progressive features; Carcino 1, Carcino 2, Carcino 3, and Carcino 4 — transitional forms — tumor-bearing organisms; Evo 1, Evo 2, Evo 3, and Evo 4 — successive stages of progressive evolution. Arrows indicate participation in the corresponding processes or essential connections. Curved arrows indicate the ability to reproduce.

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3. Fig. 2. Carcino-evo-devo diagram describing tumor-like organs and atypical tumor organs (according to: Kozlov, 2022a, with changes). devo — normal ontogenesis; cancer — ontogenesis with inherited tumors; evo — progressive evolution of development; devo’ — tumor-like organs; carcino’ — atypical tumor organs.

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4. Fig. 3. Formula (I) of multi-level stepwise increase in structural and functional complexity of multicellular organisms in progressive evolution (according to: Kozlov, 2023b, with changes).

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5. Fig. 4. Formula (II) of multi-level stepwise increase in structural and functional complexity of multicellular organisms in progressive evolution.

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