Of the huge order of parasitoform mites in the circulatory chain of the occurrence of existing pathogens and new pathogens of infections joining them, a significant role belongs to ixodic mites (I. persulcatus Sch., I. ricinus Lin.). These blood-sucking parasites are the main carriers of more than 10 nosological forms of zoonotic infections identified in the Republic of Tatarstan. Of these, a special place in the regional pathology is occupied by Lyme borreliosis and tick-borne encephalitis. Despite the relative duration of monitoring of natural focal infections in Tatarstan, the problem of this group of diseases has not disappeared and requires close attention and analysis of the current epidemiological and epizootological state. Based on our own research and stock materials of sanitary and epidemiological services, the ranking of enzootic territories representing a certain degree of risk of infection of the population in the Republic of Tatarstan by tick-borne encephalitis and Lyme borreliosis in the context of administrative territories was carried out. In the region, for the period of 2017–2021, there was a decrease in the intensity of infection of the tick-borne encephalitis population (5 cases in 5 years). At the same time, a high degree of risk of infection of the population with Lyme borreliosis was revealed.