The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges

  • Авторы: Khiji M.1, Arghidash F.2, Tanha G.3, Zadeh R.4, Ghorbani E.5, Khazaei M.5, Hassanian S.3, Gataa I.6, Lam A.7, Giovannetti E.8, Ferns G.9, Nazari E.10, Avan A.5
  • Учреждения:
    1. Student Research Committee, Sabzevar University of Medical Sciences
    2. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine,, Mashhad University of Medical Sciences
    3. Metabolic Syndrome Research Center,, Mashhad University of Medical Sciences
    4. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences
    5. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences
    6. College of Medicine, University of Warith Al-Anbiyaa
    7. Department of Pathology, School of Medicine and Dentistry, Griffith University
    8. Cancer Pharmacology Lab, AIRC Start Up Unit, Fondazione Pisana per La Scienza
    9. Division of Medical Education, Brighton and Sussex Medical School
    10. Department of Health Information, Technology and Management, School of Allied Medical Sciences,, Shahid Beheshti University of Medical Sciences
  • Выпуск: Том 30, № 17 (2024)
  • Страницы: 1295-1306
  • Раздел: Immunology, Inflammation & Allergy
  • URL: https://snv63.ru/1381-6128/article/view/645668
  • DOI: https://doi.org/10.2174/0113816128296710240404040232
  • ID: 645668

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Полный текст

Аннотация

Hydrogen therapy has emerged as a possible approach for both preventing and treating cancer. Cancers are often associated with oxidative stress and chronic inflammation. Hydrogen, with its unique physiological functions and characteristics, exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties, making it an attractive candidate for cancer treatment. Through its ability to mitigate oxidative damage, modulate inflammatory responses, and sustain cellular viability, hydrogen demonstrates significant potential in preventing cancer recurrence and improving treatment outcomes. Preclinical studies have shown the efficacy of hydrogen therapy in several cancer types, highlighting its ability to enhance the effectiveness of conventional treatments while reducing associated side effects. Furthermore, hydrogen therapy has been found to be safe and well-tolerated in clinical settings. Nonetheless, additional investigations are necessary to improve a comprehensive understanding of the mechanisms underlying hydrogen's therapeutic potential and refine the administration and dosage protocols. However, further clinical trials are still needed to explore its safety profile and capacity. In aggregate, hydrogen therapy represents an innovative and promising treatment for several malignancies.

Об авторах

Morteza Khiji

Student Research Committee, Sabzevar University of Medical Sciences

Email: info@benthamscience.net

Faezeh Arghidash

Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Ghazaleh Tanha

Metabolic Syndrome Research Center,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Rasoul Zadeh

Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Elnaz Ghorbani

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Majid Khazaei

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Seyed Hassanian

Metabolic Syndrome Research Center,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Ibrahim Gataa

College of Medicine, University of Warith Al-Anbiyaa

Email: info@benthamscience.net

Alfred Lam

Department of Pathology, School of Medicine and Dentistry, Griffith University

Email: info@benthamscience.net

Elisa Giovannetti

Cancer Pharmacology Lab, AIRC Start Up Unit, Fondazione Pisana per La Scienza

Email: info@benthamscience.net

Gordon Ferns

Division of Medical Education, Brighton and Sussex Medical School

Email: info@benthamscience.net

Elham Nazari

Department of Health Information, Technology and Management, School of Allied Medical Sciences,, Shahid Beheshti University of Medical Sciences

Автор, ответственный за переписку.
Email: info@benthamscience.net

Amir Avan

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences

Автор, ответственный за переписку.
Email: info@benthamscience.net

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